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pentobarbital will minimize the extent or effect of parecoxib by impacting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Check.pentobarbital will lower the extent or effect of nisoldipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital decreases levels of vandetanib by impacting hepatic/intestinal enzym